CromCarbon™

Pioneering 100% Graphitized Carbon Chromatography

Engineered for unmatched chemical stability, breakthrough selectivity, and transformative performance — CromCarb™ redefines the future of small and large molecule separations.

Overview

CromCarb™ is a family of high-performance chromatography columns based on 100% graphitized carbon media. Unlike traditional silica-based or polymeric packings, these all-carbon stationary phases offer a unique combination of extreme chemical stability and broad analyte affinity, enabling efficient separation of both non-polar and polar compounds

CromCarb™ Columns

CromCarb™ Column Family

Introducing the CromCarb™ Range — Precision Built, Application Tuned.

CromCarb™ Select

Small molecules, general reversed-phase separations

Silica-free durability, wide chemical compatibility

CromCarb™
Bio

Peptides, proteins, biologics

Wide-pore, bio-optimized all-carbon design

CromCarb™
Multi

Complex mixtures, multimodal separations

Reversed-phase + ion-exchange hybrid behavior

CromCarb™
Electro

Charged analytes, selective capture & release

Electrically modulated chromatography

CromCarb™
Special

Expanding Pure Carbon Excellence Across Workflows

Versatile Carbon Technology for Every Scale & Application.

Why Choose Pure Carbon? Unlock New Chromatographic Dimensions.

Chromatography is evolving — and CromCarb™ leads the charge. Unlike traditional silica-based columns, CromCarb™ harnesses the full potential of 100% graphitized carbon to offer:

  • pH 0–14 compatibility no restrictions, from strong acids to strong bases.
  • Temperature resilience up to 200°C high stability under extreme conditions.
  • Universal retention seamlessly retains both hydrophobic and hydrophilic compounds.
  • Phase-collapse immunity reliable operation in 100% aqueous mobile phases.
  • Shape selectivity and isomer resolution separating where silica fails.

Whether you’re tackling small molecules, peptides, proteins, or charged analytes, CromCarbon™ provides unrivaled versatility, durability, and chromatographic precision.

CromCarb™ HPLC Columns Comparison (Select | Bio | Multi | Electro)

Feature
CromCarb™ Select
CromCarb™ Bio
CromCarb™ Multi
CromCarb™ Electro
Core Technology
100% Graphitized Carbon
100% Graphitized Carbon (Bio-Optimized)
Epoxy-Activated Carbon
High Conductivity Carbon
Particle Sizes
5 µm, 10 µm, 40 µm, 75 µm
5 µm, 10 µm
5 µm, 10 µm
5 µm, 10 µm
Surface Area
~200–250 m²/g
~100–150 m²/g
Tunable
Tunable
Pore Size
~200 Å
300 Å / 500 Å / 1000 Å
Tunable (Based on Ligands)
Tunable
pH Stability
0–14
0–14
0–14
0–14
Temperature Stability
Up to 200°C
Up to 200°C
Up to 200°C
Up to 200°C
Pressure Tolerance
≥400 bar
≥400 bar
≥400 bar
≥400 bar
Key Mechanism
Hydrophobic, π-π Retention
Bio-molecule Specific Retention
Multimodal (Hydrophobic + Ionic + Affinity)
Voltage-Controlled Ion Capture/Release
Best Suited For
Small Molecules, Polar/Nonpolar Compounds, Isomers
Peptides, Proteins, Oligonucleotides, ADCs
Charge Variants, Glycoforms, Biologics
DNA/RNA Cleanup, Charged Peptides, Desalting
Unique Advantage
No phase collapse under 100% aqueous
Ion-pairing free peptide mapping
Mixed-mode separation in one run
Electrically modulated retention (no salt needed)
Formats Available
Analytical, Flash, Prep
Analytical, Flash, Prep
Analytical, Flash, Prep
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Transform challenges into opportunities.

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