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Mixed-mode chromatography is defined as separation technique where at least two controllable interactions exist in order to adjust selectivity and retention of compounds. Mixed-mode chromatography can combine reversed-phase or HILIC interaction with ion-exchange, ion-exclusion or pi-pi interaction.
Mixed-mode stationary phases have ionizable groups on the surface, allowing analysis with both aqueous and fully organic mobile phase. Polar groups on the surface prevent phase collapse that could occur in reversed-phase columns.
Mixed-mode chromatography provides retention and separation for a much wider range of compounds than single-mode chromatography. You can retain and separate neutral hydrophobic, hydrophobic ionizable, polar, and polar ionizable compounds, along with positively and negatively charged inorganic ions, within one run.
HILIC mixed-mode columns are the ideal choice for separation of polar neutral, polar ionizable, and hydrophobic ionizable compounds, and positively and negatively charged inorganic ions.
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