CromSil™ Bio Columns

Precision Solutions for Biomolecule Analysis

Elevating Bio-Separations with Unmatched Accuracy and Efficiency

Overview

At Chrom Science & Technology, we understand that the precision required in biomolecular chromatography demands more than just a column — it requires a platform engineered for molecular excellence.

CromSil™ Bio Columns are meticulously developed to meet the high-performance demands of peptides, proteins, antibodies, nucleotides, and other complex biomolecules. Whether you’re running cutting-edge therapeutic development, high-throughput QC analytics, or complex protein fingerprinting, our bio column portfolio ensures outstanding resolution, exceptional peak shape, and maximum recovery — every single time.

Engineered with precision pore control

Available in 160Å, 200Å, 300Å, and 1000Å pore sizes

Supports Fully Porous, Core-Shell, and Fully Solid particle technologies

Compatible with a wide range of bonded chemistries (C18, C8, C4, Silica, Protein A)

From discovery to production, CromSil™ Bio delivers confidence.

CromSil™ AxisBio (160Å)

High-Efficiency Separation of Small to Mid-sized Biomolecules

CromSil™ BioSphere (200Å)

Versatile Performance for Intermediate-Sized Peptides and Proteins

CromSil™ Bio-Genysis (300Å & 1000Å)

Optimized for Large Biomolecules and Complex Protein Separations

Bio Columns Available Across All CromSil™ Particle Technologies

CromSil™ Bio Columns can seamlessly integrate into all available particle technology platforms offered by Chrom Science & Technology:

  • Fully Porous Particles: (CromSil™ Purity, Pro, Beta) available in (CromSil™ AxisBio|| Bio-Genysis || BioSphere||
    Maximum surface area and high sample loading capacity. Ideal for detailed method development and precise biomolecule separations.
  • Core-Shell (Superficially Porous) Particles: (CromSil™ ShellMaster) available in (CromSil™ AxisBio|| Bio-Genysis || BioSphere|| Enhanced efficiency, sharper peak shapes, and faster mass transfer for rapid, high-throughput separations.
  • Fully Solid (Non-Porous) Particles: (CromSil™ CoreSphere):  available in (CromSil™ AxisBio|| Bio-Genysis || BioSphere||
    Exceptional mass transfer kinetics, excellent for very large biomolecules requiring rapid diffusion and reduced sample interaction with pores.

Technical Quick-Reference Sheet

Feature
AxisBio (160Å)
BioSphere (200Å)
Bio-Genysis (300Å/1000Å)
Particle Type
Fully Porous, Core-Shell, Fully Solid
Fully Porous, Core-Shell, Fully Solid
Fully Porous, Core-Shell, Fully Solid
Available Chemistries
C18, C18(XpH) C8, C4, C1, C30, Aqua, Phenyl, Phenyl Hexyl, Phenyl Hexyl +, Biphenyl, PFP, Cyano, Diol, Amino, Silica
C18, C8, C4
C18, C18(XpH) C8, C4, C1, C30, Aqua, Phenyl, Phenyl Hexyl, Phenyl Hexyl +, Biphenyl, PFP, Cyano, Diol, Amino, Silica
Typical Particle Sizes
1.7 µm, 1.9 µm, 3 µm, 5 µm
3 µm, 5 µm
1.7 µm, 1.9 µm, 3 µm, 5 µm
Recommended Flow Rate
0.2–1.5 mL/min
0.5–2.0 mL/min
0.2–1.5 mL/min
Pressure Stability
Up to 700 bar
Up to 400 bar
Up to 700 bar
Operational pH Range
pH 2–10
pH 2–10
pH 2–10
Typical Applications
Peptides, small to medium proteins (~30 kDa)
Peptides, mid-sized proteins (~80 kDa)
Medium to very large proteins, antibodies, therapeutics

Why Choose CromSil™ Bio Columns?

  • Precision-Engineered: Optimized pore structures specifically for bio-separations
  • Versatile: Broad applicability across pharmaceutical, biotechnology, clinical, and environmental labs
  • Consistent & Reproducible: Meticulous QC ensures reliable results batch-to-batch
  • Comprehensive: Extensive phase and particle type availability tailored for your exact analytical needs.

Ready to Elevate Your Biomolecule Separations?

Discover how CromSil™ Bio Columns can optimize your analytical workflows, delivering precision, efficiency, and reliability for your critical bio-separations. Whether you are working with peptides, proteins, antibodies, or complex biological samples, our expert technical team is here to help you select the ideal column configuration tailored to your specific needs.

Request Your Free Consultation:
Let our chromatography specialists guide you in choosing the perfect CromSil™ Bio Column for your application.

Explore Custom Solutions:
Need specialized column dimensions or unique stationary phase chemistries? We offer tailored solutions designed specifically for your analytical challenges.

Experience the CromSil™ Difference:
Order your CromSil™ Bio Columns today and experience unmatched reproducibility, peak clarity, and method robustness for all your bioanalytical needs.

Chrom Science & Technology – Your Partner in Precision Chromatography.

ChromScience

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