Versatile Performance for Intermediate-Sized Peptides and Proteins
CromSil™ BioSphere columns utilize highly purified spherical silica particles with an optimized 200Å pore structure, designed explicitly for efficient, precise separations of peptides and medium-sized proteins (~80 kDa). BioSphere’s advanced particle design ensures reliable results with reduced back pressure and minimal sample degradation.
✔ Exceptional peak shape and minimal nonspecific interactions
✔ Robust, reproducible analytical results
✔ High mechanical stability and easy scalability for method transfer
✔ Broad selectivity options to handle diverse bio-separations
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Chemistry
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Separation Mechanism
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pH Range
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Carbon Load
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Endcapping
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Performance & Benefits
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|---|---|---|---|---|---|
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C18
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Strong hydrophobic reversed-phase
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2–8
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High
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Fully endcapped
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High resolution; excellent for peptide mapping and protein profiling
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|
C8
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Moderate hydrophobic interaction
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2–8
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Moderate
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Fully endcapped
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Faster elution; suitable for medium polarity biomolecules and peptide fragments
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|
C4
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Weak hydrophobic interaction
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2–8
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Low to Moderate
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Fully endcapped
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Optimized for large protein separations and improved recovery
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