CromSil™ StoneSep

CromSil™ StoneSep (Mixed-Mode Core-Shell) HPLC Columns

Advanced Separation Efficiency with Unique Selectivity

The StoneSep series represents a fusion of mixed-mode chromatography and core-shell particle technology, offering unparalleled separation performance for complex mixtures. These columns are engineered to provide unique selectivity and high efficiency, making them ideal for analyzing diverse compounds across various industries.

StoneSep Column Variants:

StoneSep Columns bring together mixed-mode selectivity and core-shell efficiency for faster, high-performance separations.

StoneSep 100

Interaction Mechanisms: Reversed-phase and cation-exchange.
Ideal For: Improving retention of basic compounds, separating acids via ion-exclusion, and retaining neutral compounds through reversed-phase mechanisms.
Compatibility: Suitable for LC-MS and preparative chromatography applications.

StoneSep S

Interaction Mechanisms: HILIC, cation-exchange, and anion-exclusion.
Ideal For: Separating common sugars, neutral or highly polar molecules, amino acids with low-concentration buffers, weak bases via ion-exchange, and acids through ion-exclusion mechanisms.
Compatibility: Suitable for LC-MS and preparative chromatography applications; operates effectively within a pH range of 2.0 to 7.0.

StoneSep SB

Interaction Mechanisms: Reversed-phase and anion-exchange.
Ideal For: Enhancing retention of acidic compounds via anion-exchange, separating bases through ion-exclusion, and retaining neutral compounds using reversed-phase mechanisms.
Compatibility: Suitable for LC-MS and preparative chromatography applications; operates effectively within a pH range of 1.5 to 5.0.

Applications:

StoneSep columns are versatile tools suitable for the separation of complex mixtures containing various components, including polar, non-polar, hydrophobic, hydrophilic, organic, and inorganic substances, within a single analytical run.

Why Choose StoneSep Columns?

StoneSep Columns bring together mixed-mode selectivity and core-shell efficiency for faster, high-performance separations.

✔ Hybrid Selectivity – Combines Reversed-Phase, Ion-Exchange, and HILIC interactions for unmatched separation power.

✔ Core-Shell Efficiency – Delivers sharper peaks, faster separations, and higher resolution at lower backpressure.

✔ Enhanced Retention – Superior retention for polar, non-polar, acidic, and basic compounds without ion-pairing reagents.

✔ LC-MS Compatibility – Designed for cleaner mass spectrometry detection with reduced background noise.

✔ Versatile Applications – Ideal for pharmaceuticals, food analysis, chemical research, and method development.

Key Features:

Enhanced Selectivity: By integrating multiple interaction mechanisms—such as reversed-phase, ion-exchange, and HILIC—StoneSep columns offer alternative selectivity beyond traditional reversed-phase or HILIC columns.
High Efficiency: The core-shell particle design enables high efficiency at elevated flow rates while maintaining back pressures compatible with conventional HPLC systems, eliminating the need for specialized UPLC equipment.
Increased Capacity: Optimized ligand density and balanced ionic/hydrophobic ratios address potential loadability issues, ensuring higher capacity and retention compared to traditional reversed-phase columns.

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