Advanced Multi-Mode Selectivity for Complex Separations
The Prime series of mixed-mode HPLC columns is engineered to handle complex separations by integrating multiple retention mechanisms within a single stationary phase. These columns efficiently separate polar, non-polar, hydrophilic, hydrophobic, organic, and inorganic compounds, making them ideal for pharmaceutical, chemical, food, and research applications.
With a unique combination of reversed-phase, ion-exchange (cationic and anionic), hydrogen bonding, and HILIC interactions, Prime columns allow for highly selective, efficient, and robust separations, eliminating the need for multiple columns or complex mobile phase modifications.
Optimize your chromatography workflows with the powerful selectivity and flexibility of Prime Mixed-Mode Columns.
✔ Dual-Mode Interactions – Reversed-Phase and Cation-Exchange.
✔ Ideal for – Hydrophilic & hydrophobic basic compounds, weak acids, and neutral molecules.
✔ pH Range – Stable across highly aqueous to fully organic conditions.
✔ Triple-Mode Interactions – Reversed-Phase, Cation-Exchange, and Anion-Exchange.
✔ Versatile Selectivity – Separates neutral, acidic, and basic compounds in a single run.
✔ Optimized for – High ligand density ensures strong retention and robust method reproducibility.
✔ Quadruple-Mode Interactions – Reversed-Phase, π-π stacking, Cation-Exchange, and Anion-Exchange.
✔ Best for – Separating structurally similar compounds with slight chemical differences.
✔ Highly Flexible – Retention time can be adjusted using solvent type, buffer concentration, and pH modifications.
✔ Triple-Mode Interactions – HILIC, Cation-Exchange, and Anion-Exchange.
✔ Ideal for – Highly polar compounds, weak acids, weak bases, and amphoteric molecules.
✔ High Loadability – Strongly retained polar functional groups allow for higher sample capacity.
✔ Dual-Mode Interactions – Cation-Exchange and Hydrogen Bonding.
✔ Applications – Effective in Normal-Phase, HILIC, or Cation-Exchange modes.
✔ Robust Performance – Compatible with 100% water or organic solvents without phase collapse.
✔ Dual-Mode Interactions – Anion-Exchange and Hydrogen Bonding.
✔ Designed for – Effective separations in Normal-Phase, HILIC, or Anion-Exchange modes.
✔ Highly Stable – Fully compatible with aqueous and organic solvent systems.
Optimize your chromatography workflows with the powerful selectivity and flexibility of Prime Mixed-Mode Columns.
✔ Unmatched Selectivity – Multi-mode retention mechanisms provide better resolution in single-run separations.
✔ LC-MS Compatibility – Eliminates the need for ion-pairing agents, ensuring cleaner mass spectra.
✔ Method Flexibility – Retention and resolution can be adjusted using pH, buffer, and organic solvent variations.
✔ High Efficiency & Stability – Designed for long-lasting performance, even under extreme conditions.
✔ Multi-Mode Separation Mechanisms – Combines Reversed-Phase, Ion-Exchange, HILIC, and Hydrogen Bonding interactions.
✔ Enhanced Selectivity – Retains and separates a wide range of analytes, including neutral, acidic, and basic compounds.
✔ Eliminates Ion-Pairing Reagents – Retains charged analytes without requiring LC-MS incompatible additives.
✔ Flexible Method Development – Adjusts selectivity by modifying pH, buffer concentration, and organic solvents.
✔ Stable Under Varied Conditions – Compatible with 100% aqueous and 100% organic mobile phases.
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