Cyano (USP L10)

Cyano (USP L10) – Balanced Polarity for Versatile Separations

Overview

Cyano (CN) columns offer a unique balance of polar and non-polar interactions, making them highly versatile for both normal-phase and reversed-phase chromatography. Their moderate hydrophobicity and polar functionality allow for a broad range of separations.

Key Properties

  • Separation Mechanism: Combination of hydrophobic and dipole-dipole interactions.
  • pH Range: pH 2–8, stable under mild acidic and neutral conditions.
  • Carbon Load (100Å Pore Size): Optimized to retain both polar and non-polar analytes.
  • Endcapping: Fully endcapped to minimize secondary interactions.

Performance & Benefits

Ideal for Both Normal-Phase and Reversed-Phase Applications High versatility.

Moderate Hydrophobicity Less retention than C18, allowing better selectivity.

Enhanced Peak Symmetry Reduces tailing for polar compounds.

USP L10 Compliance Meets regulatory standards for analytical applications.

Recommended Application Areas

  • Pharmaceuticals Separation of polar drug compounds.
  • Environmental Analysis Detection of pesticides and organic pollutants.
  • Food & Beverage Analysis of vitamins and additives.
ChromScience

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