Diol (USP L20)

Diol (USP L20) – Versatile for Normal-Phase and HILIC Separations

Overview

Diol columns offer enhanced retention of polar compounds in both normal-phase and hydrophilic interaction liquid chromatography (HILIC) modes. They provide better reproducibility compared to bare silica and support various mobile phases.

Key Properties

  • Separation Mechanism: Polar interactions dominate for HILIC and normal-phase separations.
  • pH Range: pH 2–8, suitable for aqueous and non-aqueous mobile phases.
  • Carbon Load (100Å Pore Size): Optimized for polar analyte retention.
  • Endcapping: Not endcapped to maintain strong polar interactions.

Performance & Benefits

Excellent Retention for Hydrophilic Analytes Ideal for sugars, peptides, and organic acids.

Compatible with Both Normal-Phase and HILIC Modes Versatile for various applications.

Superior Peak Shapes Reduces tailing for polar compounds.

Regulatory Compliance Meets USP L20 requirements.

Recommended Application Areas

  • Pharmaceuticals Polar drug metabolites and small peptides.
  • Food & Beverage Carbohydrate and sugar analysis.
  • Environmental Analysis Detection of hydrophilic pollutants.
ChromScience

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