Biphenyl (USP L11)

Biphenyl (USP L11) – Dual π-π Interactions for Enhanced Aromatic Selectivity

Overview

Biphenyl columns offer stronger π-π interactions than single phenyl phases, making them ideal for separating structurally similar aromatic compounds and enhancing selectivity in complex mixtures.

Key Properties

  • Separation Mechanism: Dual π-π interactions with hydrophobic retention.
  • pH Range: pH 2–8, compatible with organic and aqueous eluents.
  • Carbon Load (100Å Pore Size): High carbon loading for greater selectivity.
  • Endcapping: Fully endcapped for improved peak shape.

Performance & Benefits

Enhanced Separation of Aromatic Compounds Superior to single-phenyl columns.

Selective for Polar and Non-Polar Analytes Works for diverse sample types.

USP L11 Compliance Suitable for regulated applications.

Increased Retention & Resolution Improves peak symmetry in LC-MS analysis.

Recommended Application Areas

  • Pharmaceuticals Drug impurity and metabolite profiling.
  • Environmental Testing Trace analysis of aromatic pollutants.
  • Food & Beverage Complex polyphenol separations.
ChromScience

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